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In LOsG-induced prediabetes, although pancreatic ROS stress remained high on LOsG treatment day 38, there were no alterations in mRNA levels of ER stress (XBP1 and BIP), inflammation (IL6 and IL1), and hypoxia-responsive (HIF1 and GAPDH) genes between LOsG- and sham-treated groups
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Two patients did not complete the treatment period due to side effects, and five more did not complete the posttreatment measurements
