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amino acid starvation stress) and the production of effector catabolites (see Figure 2 )

We also showed that some CRC cells were relatively dependent on energy metabolism as an energy source, especially CSCs, and demonstrated high expression of ASCT2 in CSC population and the CSC-suppressing effect of the glutaminase (GLS) inhibitor 7

doi: 10.1016/j.biopha.2020.110031 340 GongJZhangWGFengXFShaoMJXingC

Outcome: Convenient 5-minute alternative to IV

Molecular docking suggested that a vinyl group, rather than an ethyl linker, would better extend into the Q2 pocket, resulting in molecules with improved metabolic stability and inhibitory potency