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If it heats up on your tongue, you know it has bioactivity The warmer it gets, the more bioactive it is

10.1177/2472555218755629 20 BungardC

Handb Exp Pharmacol [Internet]

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PGC-1 is a key controller of mitochondrial biogenesis and the reactive oxygen species (ROS) stress response and is controlled by SIRT1/3, TFAM, and AMPK