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Taking high doses of Folate without adequate Vitamin B12 can exacerbate the "Folate Trap" and potentially worsen neurological symptoms

Those animals resisted diet-induced obesity, stayed leaner than controls, and burned more energy even on a high-fat diet (Kraus et al., 2014)

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[20] Treatment of megaloblastic anemia with concurrent vitamin B 12 deficiency using B 12 vitamers (including cyanocobalamin), creates the possibility of hypokalemia due to increased erythropoiesis (red blood cell production) and consequent cellular uptake of potassium upon anemia resolution

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