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Cyanocobalamin, vitamin B12, depresses glutamate release through inhibition of voltage-dependent Ca2+ influx in rat cerebrocortical nerve terminals (synaptosomes)

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Its well-characterized pharmacological profile has established 5-Amino-1MQ as a valuable research tool for studying NNMT enzyme biology, enzyme-inhibitor interactions, methylation pathway regulation, nicotinamide-associated metabolic networks, and structure-activity relationships involving NNMT-targeting compounds