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Bone marrow HSPCs were depleted in mouse xenograft models and immunocompetent cynomolgus macaques, after 12 weeks of JSP191 treatment [42, 45]

Under external stress conditions, serotonergic neurons in the dorsal raphe nucleus (DRN) can be activated and release 5-HT

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At neutral pH, the absorbance peak decreased with time, suggesting gradual depolymerization of blue melanin (Supplementary Fig
