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This mechanism is driven by IR-induced Nuclear Receptor Coactivator 4 (NCOA4)-mediated ferritinophagy regulation and has been demonstrated in both intestinal and vascular endothelial tissue, contributing to a cascade of free radical and lipid peroxide formation [44,45,46]

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6.3 Preclinical and clinical research status Currently, therapeutic strategies targeting ferroptosis have made significant progress in preclinical and clinical research

While glutathione supplementation is generally safe for most individuals, some may experience gastrointestinal side effects, including diarrhea

2017 doi: 10.1097/MCC.0000000000000373