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18, 2017, the changes provide for the expansion of the clinical trial registry and of a results databank, in order to: help individuals find clinical trials for which they might be eligible enhance the design of clinical trials to prevent the duplication of unsuccessful or unsafe trials improve the evidence base that informs clinical care increase the efficiency of drug and device development processes improve clinical research practice enhance public trust in clinical research Concurrently, The National Institutes of Health (NIH) has issued complementary policy amendments that clarify and expand the requirements for submission of clinical trial registration and results information to the ClinicalTrials.gov database

All participants provided written informed consent for brain donation upon death

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