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Since a treatment could receive a GOR of D for several reasons, we specified if the treatment received this rating because the evidence was a single case report or series (SC), demonstrated a neutral effect (NE), or was found to be possibly detrimental (DE)

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Cochrane Handbook for Systematic Reviews of Interventions , Version 6.0 (Updated July 2019)

Therefore, iron deficiency, due to inadequate dietary intake or malabsorption, can impair thyroid hormone synthesis and secretion, increasing the risk of thyroid diseases [16, 54, 55]
