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Growth Hormone and IGF Research 16(Suppl A):S55-S59. [doi.org]

The proline substitutions (Pro25, Pro28, and Pro29) in cagrilintide suppress the development of amyloid fibrils

Moreira GV, Azevedo FF, Ribeiro LM, Santos A, Guadagnini D, Gama P, et al

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The tuftsin portion provides immunomodulatory properties (tuftsin is a natural product of IgG cleavage that activates monocytes and macrophages), while the Pro-Gly-Pro extension confers neurotropic activity and enhanced stability