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This synthesis addresses the need for a concise summary of dispersed data and clarifies which nutrients demonstrate robust clinical and mechanistic support for their role in depression intervention via gut microbiota modulation, and which require further investigation

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Zileuton induces hemoglobin F synthesis in erythroid progenitors: role of the L-arginine-nitric oxide signaling pathway

Taken together, while several interventions show biological plausibility and early clinical signals, PRP is the only modality in our reference set that consistently approaches higher-tier evidence under the OCEBM 2011 framework, whereas the remaining modalities should be interpreted with moderate-to-low confidence pending larger, methodologically standardized randomized trials with longer follow-up and stronger safety reporting

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