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3 Results 3.1 Patient samples The hypothyroidism sample (N = 40) included the following co-occurring diagnoses and conditions (N = 21) made at least 1 year before starting L-carnitine supplementation in the study: hypertension (N = 6), type 2 diabetes (N = 6), sleep apnea managed with CPAP treatment (N = 3), Sjgrens Syndrome (N = 2), vitiligo (N = 2), hypercholesteremia (N = 2), menopausal symptoms (N = 2), asthma (N = 1), celiac sprue (N =1), and Menieres Disease (N = 1)

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The PLC 1 variants have been reported to have unique functions with the cardiac sarcolemma

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For immunofluorescence examination, after deparaffinization and rehydration, antigen retrieval with target retrieval solution was performed, and the sections were blocked and incubated with the respective primary antibodies overnight at 4C