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While there may exist circumstances in which copper propagates cytotoxic Fenton chemistry in vivo , this work suggests the existence of an alternative copper toxicity mechanism in E

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PC-SOD (recombinant human SOD1 covalently coupled to four molecules of lecithin) is a potent superoxide-radical scavenger with a 100-fold increase in protective effects against endothelial cell injuries, compared to unmodified SOD 567,568