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Ferrostatin-1 pretreatment preserved renal function, and decreases tubular injury and inflammation in a murine model of crystal nephropathy.54 Dual necroptosis and MPT-RN blockade was more effective than monotherapy, but ferrostatin-1 combinations were not tested.61 Heme proteins (hemoglobin and myoglobin) are endogenous nephrotoxic agents released from cells upon intravascular hemolysis or rhabdomyolysis, respectively

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