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The priming step is induced by TLRs and cytokine receptors, such as TNF receptor or IL-1 receptor, and then NF-B is activated and upregulates transcriptionally NLRP3 and pro-IL-1, which promotes NLRP3 to form inflammasome assembly

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We found that glutathione metabolism was enriched in Parkinson's disease patients, and the glutathione synthesis rate-limiting enzyme Glutamate-cysteine Ligase catalytic subunit (GCLC) was significantly down-regulated in Parkinson's disease patients