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Summary and prospect PKM2, a recognized target in cancer cell metabolic reprogramming, is also emerging as a promising therapeutic target for inflammatory diseases

Stem cell niches may reactivate in cleared tissue Months 1-6+: Gradual tissue remodeling and functional recovery in organs where senescent cell burden was reduced This cascade explains why FOXO4-DRI doesn't produce immediate, obvious effects
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We assayed axon regrowth in vivo using touch sensory PLM neurons, a well-established model for axon regeneration 37,38

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