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Currently, modern male fertility treatments involve medication that stimulates the release of hormones that enhance sperm production, like clomiphene citrate [3], and in more severe cases, assisted reproductive techniques (ART) like in vitro fertilization (IVF) alongside surgical interventions, such as varicocelectomy and vasectomy reversal

This is coupled with an exaggerated inflammatory response driven by the intestinal microbiota, leading to extensive infiltration of various immune cells, including T cells, B cells, dendritic cells (DCs), macrophages, and neutrophils, into the lamina propria

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