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Numerous studies have shown that VD deficiency, which is associated with increased inflammation, is common in patients with AD (Di Somma et al., 2017

Notably, Pyridoxine appears to compete with P5P for enzyme binding, inhibiting Pyridoxal-phosphate-dependent enzymes that are critical for neuronal function

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Indeed, it seems that the isomerization activity is catalyzed by a heme-free enzyme, whereas heme-bound mPGES-2s can degrade PGH 2 into hydroxyl heptadecatrienoic acid and malondialdehyde, instead of converting it to PGE 2 (Jania et al., 2009

[DOI] [PubMed] [Google Scholar] Rentschler LA, Hirschberger LL, Stipanuk MH