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Abstract Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with regard to mortality and prognosis, and the 5-year survival rate for all patients diagnosed with ESCC remains poor

It is thought to be more bioavailable and better absorbed than oxidized GSH

After mRNA translated into proteins, the predicted protein domains of 31 DEGs were used to indicate the difference between DEGs

doi: 10.3389/fphar.2024.1491249 Received 04 September 2024 Accepted 14 November 2024 Published 02 December 2024 Volume 15 - 2024 Edited by Anna Maria Giudetti, University of Salento, Italy Reviewed by Daniele Vergara, University of Salento, Italy Azza Awad, Al-Azhar University, Egypt Updates Copyright 2024 Mahmoud, Elshazly, El-shaarawy, Zaitone, Aldahish, Ahmed, Fawzy, Aloyouni, Abed, Saeedi and El-Sayed

Overexpressing Trx or supplementing NADPH precursors (e.g., nicotinamide mononucleotide, (NMN)) alleviates disulfidptosis in PD models, confirming redox imbalance as central [117]