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Clinical evidence from studies with NAC in depression is overall in line with preclinical findings and suggests a role of NAC as an adjunctive treatment to antidepressant therapy for symptom improvement

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The disbalance between IgG4 and other classes or subclasses of immunoglobulins, depending on how it is shaped and in which disease it occurs, may lead to various outcomes tilting the clinical picture toward inhibition of inflammation or its activation, e.g., in allergic diseases where the IgG4 role is strongly inhibitory and protective, in IgG4 RD where IgG4 is an indicator of inflammation and uncontrolled fibrosis (however, the overall role of IgG4 per se in IgG-RD is unclear) and in neoplasms, in which the pathogenic role of IgG4 is overwhelming

[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Eldin A.B., Shalaby A., Abdallah M.S., Shaldam M.A., Abdallah M.A