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TABLE 1 Potential candidates of drug repositioning for CIPN identified in preclinical studies Cytochrome-P 450 -epoxygenase 2J (CYP2J), High-mobility group box 1 (HMGB1), N -methyl-d-aspartate receptor (NMDAR), nuclear factor-erythroid-2-related factor 2 (Nrf2), organic anion-transporting polypeptide B2 (OATP1B2), organic cation transporter 2 (OCT2), phosphodiesterase (PDE), peroxisome proliferator-activated receptor gamma (PPAR), sphingosine 1-phosphate (S1P), store-operated calcium entry (SOCE), superoxide dismutase (SOD), potassium channel subfamily K member 2 (TREK1), transient receptor potential channel melastatin 8 (TRPM8)

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Pain and Discomfort : You should expect to have pain or discomfort similar to a feeling of having worked out too hard

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Retrieved November 12, 2018