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Modulators of the JAK/STAT axis and cAMP/CREB activators (e.g., rolipram and forskolin) similarly attenuate pathogenic cytokine signaling and support Treg responses, aligning with the immunological signature of exercise in EAE [257, 259]
618 This mitochondrial remodeling supports a proinflammatory state via ROS signaling
The VOI placement, detailed in Supplementary Fig
doi: 10.1016/j.mce.2020.111038 69 CoopmansECBerkKACEl-SayedNNeggersSvan der LelyAJ
[DOI] [PubMed] [Google Scholar] Irving WL, Day S, Johnston ID
