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The blood supply to the brain is derived from the internal carotid and vertebral arteries, these sources anastomosing under the brainstem and at the circle of Willis

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Nevertheless, the clinical application of NA is limited because the pharmacological dosing of it induces cutaneous flushing via activation of a G protein-coupled receptor, GPR109A

The largest number of genes (96) that exhibited altered expression (cut-off 1.50) in response to Semax administration was detected 3 h after the onset of ischemia (Additional file 1)