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doi: 10.4291/wjgp.v11.i1.1

In cases of missing cooperation or the need for sedation of the patients, these tools are replaced by those generally applicable to patients admitted to the intensive care unit such as the Richmond AgitationSedation Scale.63 The Clinical Institute Withdrawal Assessment for Alcohol scale in its revised version (CIWAAr) is the most widely used tool to clinically estimate severity of AWS based on observations of the rater and patient participation

Chronic stress causes telogen effluvium (stress-related hair shedding) and elevates inflammation throughout the body

36 Senescent cells also have a distinct inflammatory secretory profile termed the senescence associated secretory phenotype (SASP), which has a profound detrimental effect on surrounding cells, leading to altered intercellular communication

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