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Inflammatory signaling molecules such as cytokines can interfere with insulin receptor signaling, impairing glucose metabolism and contributing to insulin resistance

11beta-hydroxysteroid dehydrogenase type 1 is overexpressed in subcutaneous adipose tissue of morbidly obese patients

Intriguingly, clinical studies suggest that 22q11.2DS patients might have altered brain metabolism (6, 7, 8)

However, GLP-1 RAs may also confer neuroprotective benefits to the retina

Sacco R, Eggenhoffner R, Giacomelli L
