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Description
To overcome this, researchers are developing synthetic MOTS-c analogs designed for enhanced therapeutic properties

Collagen turnover, skin barrier integrity, and fibroblast activity vary based on age, genetics, and inflammatory state

Trends Pharmacol Sci 2021, 42: 640656
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Rather than working with a crude tissue extract, researchers synthesised a short, chemically defined tetrapeptide of reproducible composition, which makes quality control and experimental reproducibility easier
