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Pesca and coauthors, [244] demonstrated the antiangiogenic activity of five proanthocyanindins, including the new natural compounds (2S)-4,5,7-trihydroxyflavan-(4 8)-epiafzelechin, (2S)- 4,5,7 trihydroxyflavan -(4 8)-afzelechin, proanthocyanidin A2, geranin B, and proanthocyanidin