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In addition to affecting glycolysis, mutant KRAS promotes tumorigenesis and development by regulating glutamine decomposition, lipid metabolism and fatty acid biosynthesis 213,214,215,216

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By contrast, for the intravenous (IV) preparation, the UK licence recommends a dose of 4 g/day every 46 h for adults weighing above 50 kg with a dose reduction to 3 g/day in those who have risk of hepatotoxicity