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Likewise, redox-responsive PEG gates connected via disulfide bridges allowed for controlled drug delivery in intracellular reductive environments [209,210]

Although OxS is a consequence of normal body and organ physiology, severely impaired oxidative homeostasis results in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells function and viability

Blockade of LAG-3 immune checkpoint combined with therapeutic vaccination restore the function of tissue-resident anti-viral CD8(+) T cells and protect against recurrent ocular herpes simplex infection and disease

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Increasing/scavenging ROS is potentially applicable treatment, and further studies will help to provide more effective strategies for glioma treatment