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10.1016/j.molmet.2019.06.026 81
Further, they can modulate effects of thyroid hormones as well as sex steroid hormones [84]
In humans, MC4R mutations account for about 6% of severe early-onset obesity [5], supporting an important role for the central melanocortin system in the control of energy metabolism
Because LA can be synthesized in the body it is not technically considered a vitamin but because of its vital role in overall cellular metabolism it is considered as an important, but not necessary, dietary supplement
