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45 , D877D887, (2016)
Acta 967 , 64 (2017) J
Deoxycholic acid (DCA), a secondary BA, inhibits the plasma membrane Ca + ATPase (PMCA), suppressing Ca + -NFAT2 signaling and reducing cytotoxic molecules such as IFN-, TNF-, and granzyme B (GzmB), potentially impairing ICI efficacy when intratumoral DCA is high (64, 67)
When microglia remain activated for an extended period, the production of mediators is sustained longer than usual and this increase in mediators contributes to loss of synaptic connections and neuronal cell death
In addition to its direct ability to neutralize ROS (like O 2 H, O 2 - , OH, etc.), H 2 S also enhances the expression of antioxidant enzymes, for example, glutathione peroxidase (GSH-Px) or superoxide dismutase (SOD), through nuclear factor erythroid-derived 2 (Nrf2) activation and translocation, which regulates the expression of antioxidant proteins (79)
