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Decrease in total glutathione level was confirmed in the smt15-1::amiGSH1-2 #4D and #4F lines (Figure 3C)

Epigenetics refers to long-lasting changes in gene expression that are regulated by transcriptional, post-transcriptional, intra- or post-translational mechanisms (such as DNA methylation, histone modifications, and microRNA regulation) that do not involve DNA sequence alteration and are usually characterized by stability and longevity [84]