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In iron-repleted cells, IRPs are inactive, followed by the synthesis of FPN and Ft and the degradation of mRNAs for TfR1 and DMT1

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In comparison, the ER spectrum of a false positive peak in the profile processed with the NL filter of 129 Da (Figure 2b, labeled with an asterisk (*) at retention time of 9.2 min), did not exhibit the unique isotope pattern (Figure 3c)

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