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The eigengene score of module 144 indicates a concentration-dependent activation of gene expression by NFT (Fig

Differently from GSH, which enters the cells directly, SAG is more stable in blood plasma and, once entered into cell cytoplasm, is converted by cytoplasmatic thioesterases to GSH

For example, DNA-damaging agents (eg, doxorubicin and cisplatin) induce AIP5 in a p53-dependent manner in HCT116 colon cancer cells while UV- or -irradiation decreased AIP5 transcription in p53 wt fibroblast cells, suggesting DNA damage alters AIP5 expression in a cell line-dependent manner

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