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Mounting evidence suggests that cancer cells leverage mitochondrial function to regulate intracellular ROS, reprogram metabolic pathways, and modulate apoptosis and immune responses

Major antioxidant systems in skeletal muscle It is crucial for a cell to sustain redox homeostasismaintain ROS below a threshold level and keep their function as a signalling molecules, while reducing their toxic effects (Barbieri and Sestili 2012)

Therefore, early diagnosis by cystoscopy is justified in patients suspected to have Hunner lesions, without requiring them to fail other behavioral or medical treatments before recommending cystoscopy

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Lambert and Brand, 2004)