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Substantial contributions to the conception or design of the work

Additional information Journal peer review information: Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work

doi: 10.3389/fdmed.2025.1542913 Received 10 December 2024 Accepted 14 February 2025 Published 28 February 2025 Volume 6 - 2025 Edited by Roberta Gasparro, University of Naples Federico II, Italy Reviewed by Pradeep Kumar Yadalam, Saveetha Dental College and Hospitals, India Gabriela Ciavoi, University of Oradea, Romania Updates Copyright 2025 Burlui, Rarinca, Ciobica, Burlui, Dobrin and Stadoleanu

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notoginseng, interacts with the P2RY12 variant to decrease the inflammatory response by inhibiting the ERK/NF-b signaling pathway, suppressing neutrophil infiltration and NET release, and interfering with DVT formation in mice