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The endoplasmic reticulum also has tight restriction on exchange with the cytosol and it, uniquely, maintains an oxidizing redox status to support protein folding and disulfide formation
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10.1016/j.omto.2022.02.006 58 FangJ

Enzyme treatments, such as transglutaminase (TG) and tyrosinase, have been explored for their ability to reduce the allergenicity of TM by altering its structure and reducing its IgE-inducing capacity
