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demonstrated that the liberation of heme from Hb is a necessary step towards vaso-occlusion (Saraf, 2020

Ortiz, C

Selective P2X3 antagonist Eliapixant (BAY 1817080): ATP-dependent P2X3 receptors play a fundamental role in nerve fiber sensitization and pathological pain pathways

In AD, the XY chromosome combination is linked to greater neurodegenerative susceptibility than XX, likely reflecting the protective effects of a second X chromosome in females (Davis et al., 2020)

As such, it is apparent that additional experimentation focusing on genomics, environmental/nutritional components and their crosstalk is warranted to determine the causal factor(s) that reduce both cystine and selenoprotein levels in children affected with konzo to unravel the biological mechanism behind this disease