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In vitro expansion of chondrocytes, a necessary step in ACI, results in the generation of senescent cells that adversely affect the quality and quantity of newly formed cartilage

doi: 10.1016/S1071-9164(96)80080-7

Moreover, besides the enhanced activity of fibroblasts, which are considered essential for collagen synthesis, tissue repair, and regeneration, there was also a potential rise in mast cell activation

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