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In most cases, the formation of these AGEs on Lys and/or Arg implies the depletion of their positive charges, thus turning these residues into neutral, zwitterionic, or even anionic residues

Another issue is the loss of habitat due to construction, fires, and other circumstances

doi: 10.1038/sj.ijir.3901200

Med Hypotheses (2020) 144:110055

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