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The circuit originates from dopaminergic neuronal somata specifically in the VTA of the midbrain

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Mainly, ALC and NAC have synergistic glutamatergic modulatory activity on the xc-/mGlu2 network via epigenetic mechanisms [165], exerting neuron and astrocyte protective effects

however, resistance to chemotherapeutic agents is a significant challenge that hampers treatment efficacy

This balanced approach could ensure safer and more effective utilization of LC in healthcare