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& Mietus, L

These data demonstrate that H 2 O 2 induces TM3 Leydig cell senescence in vitro and that, in these senescent Leydig cells, FOXO4 is translocated to the nucleus and activates a senescence-associated pathway

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tirzepatide adds GIP (dual agonist) and retatrutide adds glucagon (triple agonist), with generally larger weight effects in trials but different tolerability profiles