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Curr Pharm Des 2020;26(23):2641-2683

The core mechanism of osteoporosis (imbalance of bone metabolism) Osteoporosis is essentially a negative balance between bone formation and bone resorption, resulting in continuous loss of bone mass, destruction of bone microstructure, increased bone fragility, and increased risk of fractures

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Furthermore, overexpression of RBM15 in the THP-1 macrophage cell line led to an upregulation of M1-type macrophage-associated markers CXCL9 and CXCL10, accompanied by a downregulation of M2-type macrophage-associated markers CXCL13 and MRC1