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Its levels decline significantly as we age

However, upon deletion of PNPLA2 from WAT and BAT, mice were cold sensitive under fasting conditions, suggesting that WAT-derived FAs additionally function to support BAT thermogenesis (102)
This feature allows women to harness its fat-burning properties without the counterproductive urge to consume more calories

Cell 78, 561574

The medication crosses the placenta and animal studies showed fetal harm, though human data remains limited
