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Indeed, it was shown that administration of aspartame at high doses (250 and 1000 mg/kg) for eight weeks produced remarkable liver fibrosis and changes in the mRNA levels of crucial oncogenes and tumor suppressor genes, including Harvey rat sarcoma viral oncogene homolog upregulation and P27 downregulation, respectively, indicating its potential risk in progressing to liver cancer [8]

Zaldy J

Epidemiological studies suggest that higher intake of CAF reduces the risk of Alzheimers disease (Eskelinen and Kivipelto 2010)

Here, weve summarized this reports findings, as well as those detailed in another comprehensive research report published on Pharmaceutical Online, which examined drug inspection observational trends by analyzing publicly available data from fda.gov

doi: 10.1039/D1SC04515F