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LNPs can typically be designed with a specific surface charge to either increase or reduce electrostatic interactions with mucins, such as through the incorporation of chitosan or cationic amphiphilic drugs 124,191
Many trials rely on basic oxidative stress or inflammatory markers, yet use different assay methods, sampling time points, or units of analysis, complicating direct comparison
Disease course varies, with some patients experiencing spontaneous remission and others developing chronicity (Fig
In a preclinical study, 13-week-old R6/1 and wild-type mice were given 30 g/kg IN-PACAP (38 AA isoform) daily for a week, followed by behavioral and biochemical analysis
They absorb heavy metals like arsenic, lead, and cadmium from the soil
