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To determine the liver protection by rectal ozone insufflation in patients with RA, a controlled clinical trial with 100 patients was performed: n = 50 as MTX-group (MTX + Ibuprophen + folic acid) and n = 50 as ozone group receiving the same medication + rectal ozone insufflations as described above and in detail in [26,27,28]

Other warnings If the patient has any persisting illness or alarm symptoms like weight loss, vomiting, dysphagia, haematemesis, or melena, this drug should be avoided

doi: 10.1016/j.cmet.2006.02.002 178 KirkwoodT

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This means the same dose injected in a damaged site may absorb differently than the same dose in healthy tissue, making your dosage chart unreliable