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For medication-induced increases, adjusting the medication is key
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Risk of systemic copper overload is negligible when used as directed
To be specific, IFN- could induce the expressions of multiple immune checkpoints including cytotoxic T lymphocyte antigen-4 (CTLA-4), PD-L1, and PD-L1 via JAK-STAT-dependent transcriptional cascade
doi: 10.3390/molecules28010100 6 AlessandraL.LucaP.AdrianoM
