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10.1021/jasms.0c00370

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However, because we thought the cause of these low glutathione yields was excess l-Ser accumulation in cells by simultaneous overexpression of l-Ser biosynthetic genes, we constructed SHM2 and/or CYS4 overexpressing strains using the GCI/ SER3 / SER33 and GCI/ SERs as the platform strains and examined glutathione production of these strains (Fig

The most common treatment-emergent adverse events were injection site bruising and ecchymosis for the SAD and MAD portions of the study, respectively ( Table 1 )