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doi:10.1080/02791072.1991.10471587

But since that monday, my chest is feeling weird

However, taking excessively high doses over long periods may increase the risk of side effects

Some of the most commonly reported adverse effects with these new therapies are cutaneous, and can potentially limit the use of these agents and add cost to already expensive treatment regimens.1 It is important for physicians and other healthcare providers to be aware of these effects, have a basic understanding of how to manage patients with these reactions, and to know when to refer to a dermatologist

Freezing a reconstituted peptide solution causes ice crystal formation, which exerts mechanical shear forces on the peptide structure and can disrupt hydrogen bonding that maintains tertiary conformation